Chicken Pot Pie Casserole

Highlighted under: Comfort Food

Serve up comfort food at its finest with this Chicken Pot Pie Casserole, a hearty blend of tender chicken, colorful vegetables, and creamy sauce topped with flaky biscuits. This easy one-dish recipe is perfect for busy weeknights or cozy family dinners, making mealtime special and stress-free. Enjoy a warm slice of nostalgia that brings the classic flavors of chicken pot pie right to your table!

Natalie Briggs

Created by

Natalie Briggs

Last updated on 2025-12-11T09:44:47.393Z

This Chicken Pot Pie Casserole is a delightful twist on the classic chicken pot pie. With a rich and creamy filling, it's loaded with tender chicken and fresh vegetables, all nestled under a flaky layer of biscuits. Perfect for chilly evenings, this dish brings warmth and comfort to your dining table.

Comfort Food Redefined

Chicken Pot Pie Casserole takes the beloved flavors of a traditional chicken pot pie and transforms them into an easy-to-make casserole. The heartiness of the dish does not just offer comfort but also provides a nourishing meal the whole family will appreciate. Using tender shredded chicken combined with a variety of colorful vegetables ensures that every bite is both flavorful and filling. It's a fantastic way to incorporate veggies into your meal while satisfying everyone's cravings.

This dish is not only delicious but also extremely versatile. You can easily substitute the vegetables based on your family’s preferences or what you have available in your freezer. If you prefer more greens, consider adding green beans or spinach. For a southwestern twist, throw in some diced jalapeños and spices. The adaptability of this casserole lets you customize it to make it uniquely yours!

A One-Dish Wonder

One of the most appealing aspects of Chicken Pot Pie Casserole is its simplicity. As a one-dish meal, cleanup is a breeze, making it ideal for busy weeknights when time is short. The minimal effort required to prepare this dish will allow you to focus on what really matters: spending quality time with your loved ones at the dinner table. With ingredients that are readily available, you often don't have to make an extra trip to the grocery store!

Another advantage of this casserole is that it can be made ahead of time. Preparing it in advance allows flavors to meld beautifully. Simply assemble the filling and refrigerate it, then bake it right before dinner. This flexibility is perfect for those evenings when you know you'll have a busy schedule, yet you still want a warm, homemade meal waiting at home.

Perfect for Any Occasion

Whether you’re hosting a family gathering, a potluck, or simply enjoying a cozy dinner, this Chicken Pot Pie Casserole fits every occasion. It’s hearty enough to serve as a main dish, while also being fulfilling enough to satisfy even the pickiest eaters. This dish elicits a sense of warmth and nostalgia, perfect for those moments when you want to feel right at home.

Additionally, leftovers are just as delightful! You can pack it for lunch the next day or store it in the freezer for another meal. Simply reheat in the oven or microwave, and you'll enjoy the same comfort and flavor as the first serving. This makes it a fantastic addition to your weekly meal prep plan!

Ingredients

Main Ingredients

  • 2 cups cooked chicken, shredded
  • 1 cup mixed vegetables (carrots, peas, corn)
  • 1/2 cup onion, diced
  • 1/2 cup celery, diced
  • 1 can (10.5 oz) cream of chicken soup
  • 1 cup chicken broth
  • 1 tsp garlic powder
  • Salt and pepper to taste
  • 1 package refrigerated biscuit dough

These ingredients come together to create a delicious, comforting meal that the whole family will enjoy!

Instructions

Prepare the Filling

  1. Preheat your oven to 375°F (190°C).
  2. In a large skillet, combine cooked chicken, mixed vegetables, onion, celery, cream of chicken soup, chicken broth, garlic powder, salt, and pepper.
  3. Cook over medium heat until everything is well combined and heated through.

Assemble the Casserole

  1. Pour the filling into a greased 9x13 inch casserole dish.
  2. Top with the biscuit dough, separating the biscuits slightly for even cooking.

Bake and Serve

  1. Bake for 30-35 minutes or until the biscuits are golden brown.
  2. Let it cool for a few minutes before serving. Enjoy!

Serve warm and enjoy the delicious flavors of your homemade Chicken Pot Pie Casserole!

Storing and Reheating Leftovers

When it comes to storing your Chicken Pot Pie Casserole, ensure that it cools completely before transferring it to an airtight container. This helps maintain the integrity of the biscuits and the overall flavor of the casserole. You can safely store the casserole in the refrigerator for up to three days. If you wish to keep it longer, consider freezing it for up to three months.

To reheat, preheat your oven to 350°F (175°C) and cover the casserole with foil to prevent the biscuits from burning. Heat for about 20-25 minutes, or until thoroughly warmed. If you’re using a microwave, cut individual portions and reheat for a few minutes until hot. Just remember that reheating may affect the texture of the biscuits, so oven heating is preferred.

Pairing Suggestions

This Chicken Pot Pie Casserole pairs beautifully with a simple side salad, which adds freshness and crunch to the meal. A mixed greens salad with a light vinaigrette can balance the richness of the casserole nicely. Alternatively, consider serving it alongside some steamed green vegetables, such as broccoli or green beans, which complement the dish while also adding some color to your plate.

For drinks, a light white wine, such as Chardonnay, works well with this hearty dish. If you prefer non-alcoholic options, a sparkling water with a slice of lemon can refresh your palate. You may also enjoy a warm herbal tea afterward to round off the comforting experience of this delicious casserole.

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Questions About Recipes

→ Can I use leftover turkey instead of chicken?

Yes, leftover turkey works wonderfully in this recipe!

→ Is it possible to make this recipe ahead of time?

Absolutely! You can prepare the filling and store it covered in the fridge until you're ready to bake.

Chicken Pot Pie Casserole

Serve up comfort food at its finest with this Chicken Pot Pie Casserole, a hearty blend of tender chicken, colorful vegetables, and creamy sauce topped with flaky biscuits. This easy one-dish recipe is perfect for busy weeknights or cozy family dinners, making mealtime special and stress-free. Enjoy a warm slice of nostalgia that brings the classic flavors of chicken pot pie right to your table!

Prep Time15 minutes
Cooking Duration45 minutes
Overall Time1 hour

Created by: Natalie Briggs

Recipe Type: Comfort Food

Skill Level: Easy

Final Quantity: 6 servings

What You'll Need

Main Ingredients

  1. 2 cups cooked chicken, shredded
  2. 1 cup mixed vegetables (carrots, peas, corn)
  3. 1/2 cup onion, diced
  4. 1/2 cup celery, diced
  5. 1 can (10.5 oz) cream of chicken soup
  6. 1 cup chicken broth
  7. 1 tsp garlic powder
  8. Salt and pepper to taste
  9. 1 package refrigerated biscuit dough

How-To Steps

Step 01

  1. Preheat your oven to 375°F (190°C).
  2. In a large skillet, combine cooked chicken, mixed vegetables, onion, celery, cream of chicken soup, chicken broth, garlic powder, salt, and pepper.
  3. Cook over medium heat until everything is well combined and heated through.

Step 02

  1. Pour the filling into a greased 9x13 inch casserole dish.
  2. Top with the biscuit dough, separating the biscuits slightly for even cooking.

Step 03

  1. Bake for 30-35 minutes or until the biscuits are golden brown.
  2. Let it cool for a few minutes before serving. Enjoy!

Nutritional Breakdown (Per Serving)

  • Calories: 400
  • Protein: 25g
  • Carbohydrates: 35g
  • Fat: 18g